Many of the same signs as listed above in addition to conditions specific to post-surgical infections or other complications including: These signs may not by themselves be endpoints but are medical issues that suggest there are deficiencies in surgical techniques or care that require attention. Pennsylvania Technical Assistance Program, Useful links What is continuity at a point? The application of a humane endpoint (HE) for mice in vaccine trials and further challenging tasks with lethal samples is necessary to reduce or prevent pain and suffering in these animals, and is a refinement of the 3R policy enforced for animal testing in both national and international scenarios. Chronic studies where some degree of debilitation is expected. Guidance on the practice of humane techniques, including the selection of humane endpoints, is based on best current knowledge available through personal contacts with investigators, documentation provided in peer-reviewed literature, and presentations at meetings and symposia. Note: Normal, healthy experimental animals must be observed at least once a day. INTRODUCTION The CCAC policy statement Ethics of Animal Investigation states: "Animals must not be subjected to unnecessary pain or distress. 4 0 obj endobj Calculus Limits Definition of Continuity at a Point. Huck Institutes of the Life Sciences Stating that animals will be euthanized when they become moribund is not an appropriate humane endpoint as this may not reduce or alleviate any suffering that the animal will experience. Human (moral) acts are acts which are chosen by exercising one’s free will as a conseque n ce of a judgment of conscience. >����۪U�^�X�&a$]{ni����}M��c�b����刴��$M�t�ۿ�j�������_��m�;U��U}x��� D�Sw�P/�.�HT(f��Z��{�� �x�:_��D�|�u�r��ha���tU��թ�%��ɪ�57�'�/=���[b}�T>�'| ���4��Q������ %�>���M�]��"�N���]}���q�f.���n�����r��q�)�r�XW:��0JD������Pf3l���ل�7Ф��{`�}E����d�VH�,T.��B��q�s;�e�D&. }z���gFq������@*R��� >���7���y���G931�L ��t^4�i(���|��}\~������ �n��� Working conditions are at the core of paid work and employment relationships. Humane endpoints refer to one or more predetermined physiological or behavioral signs that define the point at which an experimental animal’s pain and/or distress is terminated, minimized or reduced by taking actions such as euthanizing the animal, terminating a painful procedure or giving treatment to relieve pain and/or distress (CCAC). They may also function to refine experimental studies by allowing for the establishment of earlier endpoints and provide training for personnel in the recognition of endpoints. A humane endpoint can be defined as the point at which pain and/or distress is terminated, minimized or reduced for an entity in a trial (such as an experimental animal), by taking action such as killing the animal humanely, terminating a painful procedure, or giving treatment to relieve pain and/or distress. Consortium for Building Energy Innovation Unmanned Air Systems However, an animal may have experienced much pain and distress prior to reaching a moribund state. ��-����E4¹�!.�X��g��V�p��)æ��E�����1�o��4JΆ�Z(6��%����S!�H�BD��(ҧվ�j>�РWҦ"�j�� Product Development Under the Animal Rule Guidance for Industry U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Three conditions of the Human Act. Animals in this state are often comatose (unresponsive and unaware of stimuli) and so beyond awareness of suffering. The animal shows increased respiratory rate and/or effort. To be effective, humane endpoints must be clearly defined and based on objective criteria. <> 101 Centralized Biological Laboratory  dietary absorption, transport across the respiratory surface, dermal absorption). Choose appropriate endpoints that are objective and relevant for the assessment of pain/distress in the species. 2 0 obj Animals in studies involving pain and/or distress will often require more frequent observations to effectively determine the time at which a specific endpoint has been reached. more humane endpoints to animal experiments. endobj Strategic Interdisciplinary Research Office, Technical Resources to Support Remote Research, Food/Fluid Restriction & Physical Restraint, Institute for Computational and Data Sciences, Clinical and Translational Science Institute, Consortium for Building Energy Innovation, Pennsylvania Technical Assistance Program, Funding Institutional (formerly SciVal Funding), SciVal & Funding Institutional Quick Guides, Physiological changes (e.g., body temperature, hormonal fluctuations, clinical pathology, etc…). Non-specific signs of illness such as inactivity, hunched posture or a rough coat are an indication that an animal should be examined more closely. Please note, dehydration must be. Animal cruelty, like any other form of violence, is often committed by a person who feels powerless, unnoticed or under the control of others. Investigators are responsible for ensuring these students and employees are appropriately trained and have the skill and authority to treat or euthanize animals who have reached an endpoint. Note: Certain debilitating conditions such as tumor growth and ascites may mask true weight loss. Use of body condition scoring can provide a more accurate determination of health and fitness than body weight measurements, especially in studies where animals may develop tumor masses or fluid accumulation that obscures true weight loss. Rapid weight loss of 15-20 percent within a few days. Selection criteria (i) to represent a masterpiece of human creative genius; (ii) to exhibit an important interchange of human values, over a span of time or within a cultural area of the world, on developments in architecture or technology, monumental arts, town-planning or landscape design; Email: osvpr@psu.edu, Report a Research Concern Scoring techniques for many species, including rodents, have since been published and are widely used to assess health and fitness in animals. A number of pub-lications have defined techniques for refined determination of experimental endpoints for specific types of … A humane endpoint is defined in the 8th edition of The Guide for the Care and Use of Laboratory Animals as “the point at which pain or distress in an experimental animal is prevented, terminated, or relieved”. The degree of weight loss should be specified in terms of % or quantity (grams, pounds, kg). ;�6T�r)�M�h:� Can be combined with Conditional Access, which can then block users and devices that don't meet the rules. SciVal & Funding Institutional Quick Guides The term moribund refers to an animal that is near death or in the process of dying. A body condition scoring method for mice was developed by Ullman-Cullere, MH and CJ Foltz. Clinical and Translational Science Institute, Related Organizations: Disease progression can be modelled based on natural history data, which can be used as part of clinical trial simulations [15]. Body condition scoring: A rapid and accurate method for assessing health status in mice. 3 0 obj The goals are broad statements of desired conditions such as “restore the wetlands” or “sustain the trout population.” The planning phase is followed by the problem formulation phase, in which the assessors define the assessment endpoints based on the management goals. It is important to keep in mind that the clinical condition of the animal is one aspect of severity, and procedures are another. 1. People with progressive conditions can be classed as disabled. The Endpoint. Office Contacts treatment must be clearly defined, i.e., whether owner or study will be expected to cover costs; iii. Prize Opportunities Visually obvious, objective and easy to assess. 2.2 Definition of a Principal Surrogate Endpoint. Social Science Research Institute Regulated Biohazardous Materials (IBC) Some who are cruel to animals copy acts they have seen or that have been done to them. A humane endpoint is defined in the 8thedition of The Guide for the Care and Use of Laboratory Animals as “the point at which pain or distress in an experimental animal is prevented, terminated, or relieved”. 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